Identification of alternative splicing form of Stat2
نویسندگان
چکیده
منابع مشابه
Role of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Alternative splicing is an important cellular process that allows the expression of a large number of unique cell-specific proteins from the same underlying strand of DNA, and thereby drastically increases the organism’s phenotypic plasticity. Its emergence is facilitated by the modular composition of genes into numerous semi-autonomous building blocks. In artificial evolution, such modular com...
متن کاملIdentification of alternative splicing markers for breast cancer.
Breast cancer is the most common cause of cancer death among women under age 50 years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of this disease. Here, we present a new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator. Using a high-t...
متن کاملIdentification of Common Genetic Variation That Modulates Alternative Splicing
Alternative splicing of genes is an efficient means of generating variation in protein function. Several disease states have been associated with rare genetic variants that affect splicing patterns. Conversely, splicing efficiency of some genes is known to vary between individuals without apparent ill effects. What is not clear is whether commonly observed phenotypic variation in splicing patte...
متن کاملIVAS : Identification of genetic Variants affecting Alternative Splicing
2 The input data set 2 2.1 The genotype data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 The expression data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.3 The SNP marker position data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.4 The transcripts model data . . . . . . . . . . . . . . . . . . . . . ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1996
ISSN: 0014-5793
DOI: 10.1016/0014-5793(96)00121-4